|
Symbol Name ID |
Trex1
three prime repair exonuclease 1 MGI:1328317 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating antibody level |
Lymphocytosis |
Leukopenia |
Chronic lymphatic leukemia |
Chronic myelomonocytic leukemia |
Pericarditis |
Lymphadenopathy |
Generalized lymphadenopathy |
Splenomegaly |
Hepatosplenomegaly |
Hepatitis |
Lupus nephritis |
Nephritis |
Abnormality of the immune system |
Increased circulating interferon-gamma concentration |
Increased circulating Interferon-alpha concentration |
Inflammatory abnormality of the skin |
Chilblains |
Atopic dermatitis |
Skin rash |
Discoid lupus rash |
Malar rash |
Myositis |
Panniculitis |
Pneumonia |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Autoimmunity |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Rheumatoid factor positive |
Systemic lupus erythematosus |
Asthma |
Sepsis |
Recurrent lower respiratory tract infections |
| Disease(s) Associated with TREX1 | ||||||||||||||||||||||||||||||||||||||||||
| Aicardi-Goutieres syndrome | ||||||||||||||||||||||||||||||||||||||||||
| Chilblain lupus | ||||||||||||||||||||||||||||||||||||||||||
| retinal vasculopathy with cerebral leukodystrophy | ||||||||||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus |
| Mouse Phenotypes | immune system phenotype |
heart inflammation |
myocarditis |
salivary gland inflammation |
stomach inflammation |
thymus cortex hypoplasia |
lacrimal gland inflammation |
pancreas inflammation |
enlarged spleen |
increased spleen weight |
increased plasma cell number |
increased B cell number |
increased CD4-positive, alpha-beta T cell number |
increased regulatory T cell number |
increased spleen B cell follicle size |
abnormal spleen marginal zone morphology |
increased splenocyte number |
increased IgG level |
abnormal T cell activation |
increased circulating tumor necrosis factor level |
abnormal immune system organ morphology |
enlarged lymph nodes |
lymphoid hyperplasia |
abnormal interferon secretion |
increased susceptibility to autoimmune disorder |
increased susceptibility to systemic lupus erythematosus |
increased autoantibody level |
increased anti-nuclear antigen antibody level |
increased anti-double stranded DNA antibody level |
increased inflammatory response |
folliculitis |
myositis |
kidney inflammation |
glomerulonephritis |
tubulointerstitial nephritis |
bronchiolitis |
skin inflammation |
dermatitis |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||
| Trex1em3Gpt/Trex1em3Gpt | |||||||||||||||||||||||||||||||||||||||
| Trex1tm1.1Fwpe/Trex1tm1.1Fwpe | |||||||||||||||||||||||||||||||||||||||
| Trex1tm1Tld/Trex1tm1Tld | * | ||||||||||||||||||||||||||||||||||||||
| Trex1tm1.1Fwpe/Trex1+ | |||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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